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T., Holbrook, M., Baker, G., Robertson, R
suggesting that smoking and statins may have antagonistic effects on the Rac1 and RhoA pathway in influencing efferocytosis and inflammation resolution.99 CS is known to affect pathways leading to the activation and membrane localisation of the enzyme Rac, which facilitates the cytoskeletal rearrangements needed for efferocytosis.100 Statins are a potential therapy to improve AM efferocytosis, as demonstrated in AMs from mice and patients with COPD.101 Macrolides including azithromycin are another potential therapy to rescue defective efferocytosis as shown in patients with COPD,102 possibly due to an upregulation of CD206 but the mechanism remains to be fully elucidated
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